 |
  |
 |
 |
|
     1. Development background (1) Continuous improvement of laser treatment method ΆΒ High-output laser's generalization ff Many hi-output Lasers including He-Ne laser, CO2 laser are being used widely in hospitals in an attempt to treat skin disease by taking advantage of the characteristic of laser which brings about high effectiveness in treatment by irradiating the unique pulse matching particular disease. ΆΒ High output laser's evolution ff As the result of an effort to develop a new type of laser, IPL(Intense Pulsed Light) laser was developed few years ago to get over the old-type lasers' limit, each old-type laser has one pulse corresponding to only one disease, so in order to treat different skin diseases, different lasers have to be used at different time giving an inconvenience to patients, however, IPL laser irradiates several pulses to treat different skin diseases at the same time. ΆΒ Intensified research on pulse and laser ff On the other hand, an effort to search more effective pulse matching a specific disease has been increasing, and new pulses which show better treatment effect than the previous pulses have been found through the active R&D investment around world resulting in brand-new lasers made by reflecting the research result. As a good example, the high output laser using 420nm Blue Light Pulse can be mentioned. Various research and test reports verified that 420nm Blue Light Pulse is the best in exciting Porphyrin that plays a role in killing P.acne(Propionibacterium acnes), major cause of acne. ΆΒ Appearance for home-use device ff As one of trial to give more convenience to contemporary persons who are suffering from various skin diseases caused by irregular activities as well as pollutions, new skin therapy equipments for home-use are being invented, and in order to come up with the request from market, SM Medical also has come to put new home-use equipment for acne treatment into market by the name of Thera Skin which is firstly applied 420nm Blue Light Pulse to home-use equipment. (2) Research and application on 420nm Blue Light Pulse ΆΒ Blue Light Pulse between 405~420nm, especially 420nm was demonstrated as the most effective pulse compared to other pulses in acne treatment through tests and papers in many countries. - Journal of Dermatological Science 30 (2002) 129~135 - FEMS Immunology and Medical Microbiology 1460 (2002) 1~8 - Cosmetic & Laser Ther 2003: 5: 111~116 ΆΒ High output acne treatment device using 420nm Blue Light Pulse was invented by a company in Israel and it passed FDA approval. ΆΒ Blue Light Pulse, so called 'actinic' range peaking at 420nm, is verified as an essential element for the survival and good health of fish, corals and invertebrates. (3) Home-use Thera Skin development adopting 420nm Blue Light Pulse Based on many clinical papers and test results demonstrating the excellence of 420nm pulse in acne treatment, SM Medical Co., Ltd has developed new product, Thera Skin for home-use for the first time in our country so that peoples can use it on daily basis at any place. 2. Treatment principle If you directly irradiate 420nm Blue Light to acne, Porphyrin is photoexcited and mixed with Oxygen in the air forming Singlet Oxygen which kills P.acne. 3. Characteristic (1) Blue Light(420nm) It adopted 420nm Blue Light Pulse which many research papers are stating that it is more effective than Red Light(630~670nm) in exciting Porphyrin which destructS P.ance. "Visible light in the blue range induce a photo-destructive effect on P.acnes that may take part in the decrease in acne severity in summer, Blue-violet(405~420nm) has been shown to be 10 times more effective than red light(630~670nm) in triggering excitation of coproporphyrines" (J Cosmetic & Laser Ther 2003: 5: 111~116) (2) Moderate output In spite of home-use device, we tried to set up higher output(Watt) to strengthen the treatment effect in the range of keeping the safety by using relatively high capacity battery. (3) 19 LEDs We used 19 LEDs to cover wide area and intensify the effect. (4) Built-in battery Thera Skin eliminated the inconvenience comes from changing battery on regular basis by designing the device as built-in battery type, and Thera Skin increased the output by attaching high capacity battery. (5) Safety Blue Light Pulse reacts to only Porphyrin without damaging other skin tissue and there are no side-effects, moreover, irradiation frequency doesn't affect the safety since the output is properly adjusted for home-use. (6) Convenience Thera Skin is portable size, and user can control it with one hand due to the light weight, in the meantime, Thera Skin is maintaining proper size as much as it could contain all necessary parts for normal function. (7) Simplification Considering complicated function could lead to the defect of product, Thera Skin simplified the function as light irradiation and time adjustment. 4. Effect (1) P.acne destruction. 420nm Blue Light Pulse is inducing photoexcitation of Porphyrin and excited Porphyrin kills P.acne resulting in acne treatment. (2) Holding-back of reoccurrence The acne treatment by destructing P.acne is prolonging or preventing reoccurrence Of acne. (3)Time-saving Users can do treatment with Thera Skin anytime at any places 5. Clinical and relating data list * Acne phototherapy with a high-intensity, enhanced, narrow band, blue light source: an open study and in vitro investigation(Akira Kawada, Yoshinori Aragane, Hiroko Kameyama, Yoshiko Sangen, Tadashi Tezuka Journal of Dermatological Science 30 (2002) 129-135) * The effective treatment of acne vulgaris by a high-intensity, narrow band 405-420nm light source.(Monica Elman, Michael Slatkine & Yaram Harth J Cosmetic & Laser Ther 2003; 5: 111-116) * Imiquimod Applied Topically: A Novel Immune Response Modifier(S. Tyring, MD, PhD) * Skin Therapy Letter Acne PhotoClearing(APCTM ) Using a Novel, High-Intensity, Enhanced, Narrow Band, Blue Light Source(A.R. Shalita, MD, SUNY Downstate Medical Center, Brooklyn, NY, USA;Y. Harth, MD, Elisha Hospital, Haifa, Israel; M. Elman, MD, Beit-Harofim, Holon, Israel Clinical Application Notes Vol. 9 No. 1) * High intensity narrow band blue light is effective in the treatment of acne vulgaris - an in vitro and in vivo study (S. Stillman, S. Geen, Y. Harth, A.R. Shalita Journal of the Eruopean Academy of Dematology and Venerelogy, 9th Congress, EADV, Geneva 2000, Volume 14, Supplement 1, September 2000) * Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light(Helena Ashkenazi, Zvi Malik, Yaram Harth, Yeshayahu Nitzan FEMS Immunology and Medical Microbiology 1460 (2002) 1-8) |
 |
